In the era of economic globalization, economic independence entails the powerful presence of countries in commercial arenas, escaping commercial isolation, and by influencing international relations, leading to the emergence of a new form of diplomacy entitled "economic diplomacy". Accordingly, this study aims to explain and analyze independence and economic diplomacy in the light of the resistance economy, relying on the constitution and the guidelines of the leaders of the revolution, and helping to realize the strategic statement of the second step of the revolution and consequently the invulnerability of the country's economy in diplomatic relations, which has been prepared and conducted in a review, documentary, and library manner. First, the importance of institutionalizing the concept of economic independence, the role of economic diplomacy in its realization, then the theoretical foundations of the research, economic independence in the constitution, the importance and necessity of economic independence from the perspective of the leaders of the revolution, and finally the conclusion and discussion suggestions are presented. The results obtained from summarizing related studies and this research indicate that economic independence and diplomacy are realized by operationalizing the slogan "We can" in the light of the endogeneity and exogeneity of the resistance economy; and our country's diplomatic apparatus in the second step of the revolution, with an economic diplomacy approach and practical attention to domestic, regional, and international capacities, or by observing the principles of the constitution and the directives of the leaders of the revolution, can prevent the economic domination of foreigners over the country's economy.